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Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease.

Abstract:

The aim of this study was to determine whether high-temporal-resolution (HTR) cardiac cine-MRI could be used to identify subtle alterations in contractility and diastolic function in rodent models of disease. Following standard 45-min in vivo MRI measurements of left ventricular (LV) volumes, a single mid-ventricular slice was selected for 3-min HTR imaging. Cavity volume was measured every 2.4 ms, yielding approximately 60 images through the cardiac cycle. From these images, peak ejection an...

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Publication status:
Published

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Publisher copy:
10.1002/mrm.21677

Authors


Stuckey, DJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume:
60
Issue:
3
Pages:
582-587
Publication date:
2008-09-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:c1b0d08a-beb9-4c1f-83c7-bb768347e80b
Source identifiers:
106166
Local pid:
pubs:106166

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