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Journal article

Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy.

Abstract:

Androgen-deprivation therapy (ADT) is standard treatment for locally advanced or metastatic prostate cancer (PCa). Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear.To undertake quantitative tumour transcriptome profiling prior to and following ADT to identify functionally important androgen-regulated pathways or genes that may be reactivated in CRPC....

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Publication status:
Published

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Authors


Sudbery, IM More by this author
Villasevil, ME More by this author
Fleming, J More by this author
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Journal:
European urology
Volume:
66
Issue:
1
Pages:
32-39
Publication date:
2014-07-05
DOI:
EISSN:
1873-7560
ISSN:
0302-2838
URN:
uuid:c1ab9540-6abd-4d66-a21f-b89a4de7e043
Source identifiers:
429543
Local pid:
pubs:429543

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