Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of beta-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study.

Journal article

A total of 1,537 clinical isolates of Haemophilus influenzae were recovered in 30 U.S. medical center laboratories between 1 November 1994 and 30 April 1995 and were characterized in a central laboratory with respect to serotype and beta-lactamase production and the in vitro activities of 15 oral antimicrobial agents. Overall, 36.4% of the isolates were found to produce beta-lactamase. The rank order of activity of six cephalosporins on the basis of MICs was cefixime > cefpodoxime > cef...

Expand abstract

Authors: Doern, G; Brueggemann, A; Pierce, G; Holley, H; Rauch, A

• Journal: Antimicrobial agents and chemotherapy
• Volume: 41
• Issue: 2
• Pages: 292-297
• Publication date: 1997-02-01
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Child; Adolescent; Adult; Clavulanic Acids; beta-Lactamases; Anti-Bacterial Agents; Drug Therapy, Combination; Drug Resistance, Multiple; Female; Drug Resistance, Microbial; Amoxicillin; Humans; Microbial Sensitivity Tests; Child, Preschool; Haemophilus influenzae; Amoxicillin-Potassium Clavulanate Combination; Middle Aged; Male