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Alpha-lactalbumin possesses a novel calcium binding loop.

Abstract:

Calcium performs a unique role in biology, achieving biological effects through highly specific interactions with and modulation of target proteins. It has been proposed that calcium-modulated proteins possess a characteristic, evolutionarily related, binding fold, known as the EF-hand. The high-resolution X-ray structure of alpha-lactalbumin reveals a Ca2+ binding fold that resembles an EF-hand only superficially and presumably has no evolutionary relationship with it. However, there is clea...

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Publication status:
Published

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Publisher copy:
10.1038/324084a0

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Acharya, KR More by this author
Walker, NP More by this author
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Journal:
Nature
Volume:
324
Issue:
6092
Pages:
84-87
Publication date:
1986
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c1a1026a-536f-4932-9021-929ba425d4fe
Source identifiers:
3518
Local pid:
pubs:3518

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