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Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Abstract:

Introduction: Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QT prolongation remains a major cause of attrition during compound development. In silico assays could alleviate such problems. In this study we evaluated an in silico method of predicting the results of a rabbit left-ventricular wedge assay. Methods: Con...

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Publisher copy:
10.1016/j.vascn.2013.04.004

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Journal:
Journal of Pharmacological and Toxicological Methods
Volume:
68
Issue:
1
Pages:
88-96
Publication date:
2013-07-05
DOI:
EISSN:
1873-488X
ISSN:
1056-8719
URN:
uuid:c1a087ab-02c6-41c0-9b16-786361c2cb78
Source identifiers:
415357
Local pid:
pubs:415357

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