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A novel field-based molecular assay to detect validated artemisinin-resistant k13 mutants

Abstract:

Background

Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not available in malaria endemic areas.

Methods

A semi-automated workflow based on the easyMAG® platform and the Argene Solution® (bioMérieux, Marcy l’Etoi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/s12936-018-2329-y

Authors


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Wellcome Trust More from this funder
bioMérieux More from this funder
Institute Pasteur Paris More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Issue:
1
Pages:
175
Publication date:
2018-04-24
Acceptance date:
2018-04-18
DOI:
EISSN:
1475-2875
Pubs id:
pubs:846037
URN:
uri:c182d71d-defe-40c1-984a-752c1365cc40
UUID:
uuid:c182d71d-defe-40c1-984a-752c1365cc40
Local pid:
pubs:846037

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