Journal article icon

Journal article

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.

Abstract:

Although very high levels of interleukin (IL)-1β are present in the intestines of patients suffering from inflammatory bowel diseases (IBD), little is known about the contribution of IL-1β to intestinal pathology. Here, we used two complementary models of chronic intestinal inflammation to address the role of IL-1β in driving innate and adaptive pathology in the intestine. We show that IL-1β promotes innate immune pathology in Helicobacter hepaticus-triggered intestinal inflammation by augmen...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.20111453

Authors


Harrison, OJ More by this author
Schiering, C More by this author
Asquith, MJ More by this author
Expand authors...
Journal:
The Journal of experimental medicine
Volume:
209
Issue:
9
Pages:
1595-1609
Publication date:
2012-08-13
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:c16fd153-b5c3-423f-8312-ee993ba2acdb
Source identifiers:
345601
Local pid:
pubs:345601

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP