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Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection.

Abstract:

The evolution of the human immunodeficiency virus (HIV-1) during chronic infection involves the rapid, continuous turnover of genetic diversity. However, the role of natural selection, relative to random genetic drift, in governing this process is unclear. We tested a stochastic model of genetic drift using partial envelope sequences sampled longitudinally in 28 infected children. In each case the Bayesian posterior (empirical) distribution of coalescent genealogies was estimated using Markov...

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Publication status:
Published

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Publisher copy:
10.1534/genetics.105.052019

Authors


Edwards, CT More by this author
Holmes, EC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Viscidi, RP More by this author
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Journal:
Genetics
Volume:
174
Issue:
3
Pages:
1441-1453
Publication date:
2006-11-05
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:c16b49f4-0b5e-4e0b-83d5-431a7ab8c6e5
Source identifiers:
14556
Local pid:
pubs:14556

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