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Thesis

Quantitative analysis of regulated proteolysis and protein dephosphorylation during mitotic exit

Abstract:

The critical function of the cell cycle is to enable the faithful inheritance of genetic material. Correct attachment of chromosomes triggers degradation of cyclin B and entry into anaphase, the cell subsequently undergoing a series of rapidly occurring changes. Precise regulation of these events is necessary to ensure that they take place in the correct order and is crucial for the success of mitotic exit. This regulation has been attributed to the activity of both phosphatases and the an...

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James Holder More by this author

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Role:
Supervisor
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Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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