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Filamentation of asparagine synthetase in Saccharomyces cerevisiae

Abstract:

Asparagine synthetase (ASNS) and CTP synthase (CTPS) are two metabolic enzymes crucial for glutamine homeostasis. A genome-wide screening in Saccharomyces cerevisiae reveal that both ASNS and CTPS form filamentous structures termed cytoophidia. Although CTPS cytoophidia were well documented in recent years, the filamentation of ASNS is less studied. Using the budding yeast as a model system, here we confirm that two ASNS proteins, Asn1 and Asn2, are capable of forming cytoophidia in diauxic a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1007737

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
ORCID:
0000-0002-4834-8554
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS genetics Journal website
Volume:
14
Issue:
10
Pages:
e1007737
Publication date:
2018-10-26
Acceptance date:
2018-10-03
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:935974
URN:
uri:c166b49b-f134-434e-a2c1-21c4ab2c72f1
UUID:
uuid:c166b49b-f134-434e-a2c1-21c4ab2c72f1
Local pid:
pubs:935974
Language:
English

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