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The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study

Abstract:

Spinal cord pathology is a major determinant of irreversible disability in progressive multiple sclerosis. The demyelinated lesion is a cardinal feature. The well-characterised anatomy of the spinal cord and new analytic approaches allows the systematic study of lesion topography and its extent of inflammatory activity unveiling new insights into disease pathogenesis. We studied cervical, thoracic, and lumbar spinal cord tissue from 119 pathologically confirmed multiple sclerosis cases. Immun...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00401-024-02700-6

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
Publisher:
Springer
Journal:
Acta Neuropathologica More from this journal
Volume:
147
Issue:
1
Article number:
51
Publication date:
2024-03-09
Acceptance date:
2024-01-27
DOI:
EISSN:
1432-0533
ISSN:
0001-6322
Language:
English
Keywords:
Source identifiers:
1816773
Deposit date:
2024-05-30

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