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Journal article

Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus.

Abstract:

In Parkinson's disease, subthalamic nucleus (STN) neurons burst fire with increased periodicity and synchrony. This may entail abnormal release of glutamate, the major source of which in STN is cortical afferents. Indeed, the cortico-subthalamic pathway is implicated in the emergence of excessive oscillations, which are reduced, as are symptoms, by dopamine-replacement therapy or deep brain stimulation (DBS) targeted to STN. Here we hypothesize that glutamatergic synapses in the STN may be di...

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Publication status:
Published

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Journal:
Neuroscience
Volume:
203
Pages:
1-11
Publication date:
2012-02-05
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:c15cd294-0f38-4712-a943-398b5b1f9d23
Source identifiers:
330491
Local pid:
pubs:330491

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