- Abstract:
-
In Parkinson's disease, subthalamic nucleus (STN) neurons burst fire with increased periodicity and synchrony. This may entail abnormal release of glutamate, the major source of which in STN is cortical afferents. Indeed, the cortico-subthalamic pathway is implicated in the emergence of excessive oscillations, which are reduced, as are symptoms, by dopamine-replacement therapy or deep brain stimulation (DBS) targeted to STN. Here we hypothesize that glutamatergic synapses in the STN may be di...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.neuroscience.2011.12.027
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- Journal:
- Neuroscience
- Volume:
- 203
- Pages:
- 1-11
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
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1873-7544
- ISSN:
-
0306-4522
- URN:
-
uuid:c15cd294-0f38-4712-a943-398b5b1f9d23
- Source identifiers:
-
330491
- Local pid:
- pubs:330491
- Copyright date:
- 2012
Journal article
Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus.
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