Modelling the role of nitric oxide in cerebral autoregulation

Thesis

Malfunction of the system which regulates the bloodflow in the brain is a major cause of stroke and dementia, costing many lives and many billions of pounds each year in the UK alone. This regulatory system, known as cerebral autoregulation, has been the subject of much experimental and mathematical investigation yet our understanding of it is still quite limited. One area in which our understanding is particularly lacking is that of the role of nitric oxide, understood to be a poten...

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Authors: Catherall, M

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: stroke; blood flow; nitric oxide; NO; myogenic response; sensitivity analysis; vasomotion; dementia; arteriole; endothelium; autoregulation
• Subjects: Mathematical biology; Medical Engineering; Stroke; Biomedical engineering; Mathematical modeling (engineering); Biology (medical sciences)