Journal article icon

Journal article

A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections.

Abstract:

The role of CD4+ (L3/T4+) and CD8+ (Lyt-2+) T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-terminated infections in mice was investigated directly by in vivo depletion of these subsets with cytotoxic rat monoclonal antibodies (mAb). Effective physical depletion was demonstrated by flow cytometric analysis and immunohistochemical staining. Functional depletion of helper activity following anti-CD4 treatment was indicated by an abrogation of concanavalin A(Co...

Expand abstract
Publication status:
Published

Actions


Authors


Vignali, DA More by this author
Crocker, P More by this author
Bickle, QD More by this author
Cobbold, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Expand authors...
Journal:
Immunology
Volume:
67
Issue:
4
Pages:
466-472
Publication date:
1989-08-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:c156438d-ad86-4868-8932-c76e1a626e86
Source identifiers:
29929
Local pid:
pubs:29929

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP