Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy.

Journal article

Sporadic inclusion body myositis (s-IBM) is a chronic inflammatory myopathy of unknown pathogenesis. The common findings of ragged red fibres, cytochrome c oxidase-negative fibres and multiple mitochondrial DNA deletions in the muscle of patients with s-IBM have suggested that a deficit of energy metabolism may be of pathogenic relevance. To test this hypothesis we used 31P magnetic resonance spectroscopy to assess in vivo skeletal muscle mitochondrial function in the calf muscles of 12 patie...

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Authors: Lodi, R; Taylor, D; Tabrizi, S; Hilton-Jones, D; Squier, M

• Journal: Brain : a journal of neurology
• Volume: 121 ( Pt 11)
• Issue: 11
• Pages: 2119-2126
• Publication date: 1998-11-01
• DOI: 10.1093/brain/121.11.2119
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Phosphates; Adult; Energy Metabolism; Muscle, Skeletal; Phosphorus; Mitochondria, Muscle; Magnetic Resonance Imaging; Adenosine Diphosphate; Physical Exertion; Oxygen Consumption; Reference Values; Female; Middle Aged; Adenosine Triphosphate; Phosphocreatine; Magnetic Resonance Spectroscopy; DNA, Mitochondrial; Age of Onset; Sequence Deletion; Aged; Myositis, Inclusion Body; Male; Humans