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Normal in vivo skeletal muscle oxidative metabolism in sporadic inclusion body myositis assessed by 31P-magnetic resonance spectroscopy.

Abstract:

Sporadic inclusion body myositis (s-IBM) is a chronic inflammatory myopathy of unknown pathogenesis. The common findings of ragged red fibres, cytochrome c oxidase-negative fibres and multiple mitochondrial DNA deletions in the muscle of patients with s-IBM have suggested that a deficit of energy metabolism may be of pathogenic relevance. To test this hypothesis we used 31P magnetic resonance spectroscopy to assess in vivo skeletal muscle mitochondrial function in the calf muscles of 12 patie...

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Publisher copy:
10.1093/brain/121.11.2119

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
121 ( Pt 11)
Issue:
11
Pages:
2119-2126
Publication date:
1998-11-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:c153b7c9-09f4-46fc-89fd-9c850e0582bc
Source identifiers:
248136
Local pid:
pubs:248136

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