Thesis
Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters
- Abstract:
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The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopathies the more dramatic scenario as children are forced to live with the condition from an early age. Small genetic changes to the myofilament proteins in cardiac myocytes can result in either hypertrophic cardiomyopathy where the heart becomes enlarged and fails to relax efficiently, or dilated cardiomyopathy where the chambers of the heart stretch and are unable to appropriately contract. E...
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Authors
Contributors
+ Daniels, M
Department:
University of Manchester
Role:
Supervisor
+ Srinivas, S
Department:
University of Oxford
Role:
Supervisor
+ Lei, M
Department:
University of Oxford
Role:
Examiner
+ Mills, N
Department:
University of Edinburgh
Role:
Examiner
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03
- Deposit date:
- 2020-03-02
Related Items
Terms of use
- Copyright holder:
- Broyles, CN
- Copyright date:
- 2019
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