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Thesis

Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters

Abstract:

The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopathies the more dramatic scenario as children are forced to live with the condition from an early age. Small genetic changes to the myofilament proteins in cardiac myocytes can result in either hypertrophic cardiomyopathy where the heart becomes enlarged and fails to relax efficiently, or dilated cardiomyopathy where the chambers of the heart stretch and are unable to appropriately contract. E...

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Division:
MSD
Department:
N/A
Role:
Author, Contributor

Contributors

Department:
University of Manchester
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Examiner
Department:
University of Edinburgh
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03

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