Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD.

Journal article

BACKGROUND: Airway inflammation in chronic obstructive pulmonary disease (COPD) is predominately neutrophilic, but some subjects demonstrate eosinophilic airway inflammation. Whether these inflammatory phenotypes have differential cytokine and chemokine expression is unknown. OBJECTIVES: To assess the sputum concentrations of cytokines and chemokines and their response to oral corticosteroid therapy in COPD subjects with or without a sputum eosinophilia. METHODS: Cytokine and chemokine concen...

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Authors: Bafadhel, M; Saha, S; Siva, R; McCormick, M; Monteiro, W

• Journal: Respiration; international review of thoracic diseases
• Volume: 78
• Issue: 3
• Pages: 256-262
• Publication date: 2009-01-01
• DOI: 10.1159/000221902
• EISSN: 1423-0356
• ISSN: 0025-7931
• Language: English
• Keywords: Humans; Eosinophilia; Pulmonary Disease, Chronic Obstructive; Middle Aged; Aged; Sputum; Interleukin-5; Female; Reproducibility of Results; Male; Biological Markers; Aged, 80 and over; Chemokines; Adrenal Cortex Hormones