Journal article
Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus
- Abstract:
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Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the possibility of host genetic predisposition. Here, we present the results of a case–control study including 43 invasive GAS cases and 1540 controls. Using HLA imputation and linear mixed models, we find each cop...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, 848.7KB, Terms of use)
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- Publisher copy:
- 10.1038/s41435-019-0082-z
Authors
Funding
+ European Society of Clinical Microbiology and Infectious Diseases
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Grant:
Research Grant 2013
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Genes and Immunity More from this journal
- Volume:
- 21
- Pages:
- 63–70
- Publication date:
- 2019-08-29
- Acceptance date:
- 2019-06-11
- DOI:
- EISSN:
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1476-5470
- ISSN:
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1466-4879
Item Description
- Language:
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English
- Pubs id:
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pubs:1011731
- UUID:
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uuid:c1082d16-e366-4b15-a6b7-0fd094454e6f
- Local pid:
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pubs:1011731
- Source identifiers:
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1011731
- Deposit date:
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2019-06-12
Terms of use
- Copyright holder:
- Parks et al
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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