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A novel fungal prenyl diphosphate synthase in the dimorphic zygomycete Mucor circinelloides.

Abstract:

Two Mucor circinelloides structural genes involved in isoprenoid biosynthesis were isolated and characterised. The isoA gene encodes a typical eukaryotic farnesyl diphosphate synthase (EC 2.5.1.10), whereas the isoB gene deduced amino acid sequence shows similarity to fungal medium-chain prenyl diphosphate synthases. By functional complementation in Escherichia coli, the isoB gene product was shown to be a solanesyl diphosphate synthase (EC 2.5.1.11), which is the first fungal enzyme reported...

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Publication status:
Published

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Publisher copy:
10.1007/s00294-004-0498-4

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
Journal:
Current genetics
Volume:
45
Issue:
6
Pages:
371-377
Publication date:
2004-06-05
DOI:
EISSN:
1432-0983
ISSN:
0172-8083
URN:
uuid:c0eec1a1-6fb7-4a34-b2cb-d6464b4070e6
Source identifiers:
354443
Local pid:
pubs:354443

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