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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.

Abstract:

OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses. We generated OX40-/- mice and found that the formation of extrafollicular plasma cells, germinal centers, and antibody responses was independent of OX40. After infection with LCMV and influenza virus, OX40-/- mice retain primary and memory cytotoxic T cell responses with normal expansion and decline of specific CTL. In contrast, CD4+ T c...

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Publication status:
Published

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Authors


Schmitz, N More by this author
Gallimore, A More by this author
Lefrang, K More by this author
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Journal:
Immunity
Volume:
11
Issue:
6
Pages:
699-708
Publication date:
1999-12-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:c0dd1237-7e7d-4aa2-bbd8-8b9e3e6005c9
Source identifiers:
469155
Local pid:
pubs:469155

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