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Several commercially available anti-CCR5 monoclonal antibodies lack specificity and should be used with caution.

Abstract:

CCR5 (CD195) is a receptor for the chemokines RANTES, MIP-1α, and MIP-1β and is used by HIV-1 as a co-receptor for entry into macrophages and CD4+ T cells. CCR5 exists in multiple conformations in the membrane and is present at low levels on human macrophages, making it difficult to detect. Nine commercially available anti-CCR5 monoclonal antibodies were evaluated for their specificity and their recognition of CCR5 expressed by macrophages. Unexpectedly, we found that three of the nine clones...

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Publication status:
Published

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Publisher copy:
10.1089/hyb.2010.0092

Authors


Bernstone, L More by this author
van Wilgenburg, B More by this author
Journal:
Hybridoma (2005)
Volume:
31
Issue:
1
Pages:
7-19
Publication date:
2012-02-05
DOI:
EISSN:
1557-8348
ISSN:
1554-0014
URN:
uuid:c0dbeac7-f585-4063-aa49-b5dff1697361
Source identifiers:
317129
Local pid:
pubs:317129

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