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Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.

Abstract:

Three closely related mammalian R-Smads, namely Smad1, Smad5 and Smad8, are activated by BMP receptors. Here we have taken a genetic approach to further dissect their possibly unique and/or shared roles during early mouse development. A Smad8.LacZ reporter allele was created to visualize Smad8 expression domains. Smad8 is initially expressed only in the visceral yolk sac (VYS) endoderm and shows a highly restricted pattern of expression in the embryo proper at later stages. In addition, Smad8...

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Publisher copy:
10.1016/j.ydbio.2006.04.442

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Developmental biology
Volume:
296
Issue:
1
Pages:
104-118
Publication date:
2006-08-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:c0d40ee1-fdab-47d4-a540-afcd81e1ddfc
Source identifiers:
5549
Local pid:
pubs:5549

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