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Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.

Abstract:

beta-Adrenergic receptor activation regulates cardiac myocyte function through the stimulation of cAMP production and subsequent activation of protein kinase A (PKA). Furthermore, muscarinic receptor activation inhibits as well as facilitates these cAMP-dependent effects. However, it has not always been possible to correlate the muscarinic responses with the direct measurement of changes in cellular cAMP activity. Genetically encoded biosensors have recently been developed, making it possible...

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Publisher copy:
10.1152/ajpcell.00058.2005

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
American journal of physiology. Cell physiology
Volume:
289
Issue:
2
Pages:
C455-C461
Publication date:
2005-08-05
DOI:
EISSN:
1522-1563
ISSN:
0363-6143
URN:
uuid:c0c6bca1-db29-4412-81e1-add6ea1cc9f0
Source identifiers:
237073
Local pid:
pubs:237073

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