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Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Abstract:

BACKGROUND: Chronic inflammation is a characteristic of Alzheimer's disease (AD). An interaction associated with the risk of AD has been reported between polymorphisms in the regulatory regions of the genes for the pro-inflammatory cytokine, interleukin-6 (IL-6, gene: IL6), and the anti-inflammatory cytokine, interleukin-10 (IL-10, gene: IL10). METHODS: We examined this interaction in the Epistasis Project, a collaboration of 7 AD research groups, contributing DNA samples from 1,757 cases of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/1742-2094-6-22

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Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Department:
Oxford, MSD, Pharmacology
Role:
Author
Publisher:
BMC Publisher's website
Journal:
Journal of neuroinflammation Journal website
Volume:
6
Issue:
1
Pages:
22
Publication date:
2009-01-12
DOI:
EISSN:
1742-2094
Pubs id:
pubs:34850
URN:
uri:c0c41ec9-d6e0-4e14-aa84-90c27424bc64
UUID:
uuid:c0c41ec9-d6e0-4e14-aa84-90c27424bc64
Local pid:
pubs:34850
Paper number:
ARTN 22
Language:
English
Keywords:

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