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Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1.

Abstract:

Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal disorder characterized by sphingolipid and cholesterol storage in the late endocytic system. In common with other neurodegenerative diseases, activation of the innate immune system occurs in the brain resulting in neuro-inflammation. Targeting inflammation in the brain therefore represents a potential clinical intervention strategy that aims to slow the rate of disease progression and improve quality of life. We evaluated no...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2009.07.010

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neurobiology of disease
Volume:
36
Issue:
2
Pages:
242-251
Publication date:
2009-11-05
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
URN:
uuid:c0b42416-7de4-42d4-8fdd-77f8552ee1c6
Source identifiers:
185112
Local pid:
pubs:185112

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