- Abstract:
-
Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal disorder characterized by sphingolipid and cholesterol storage in the late endocytic system. In common with other neurodegenerative diseases, activation of the innate immune system occurs in the brain resulting in neuro-inflammation. Targeting inflammation in the brain therefore represents a potential clinical intervention strategy that aims to slow the rate of disease progression and improve quality of life. We evaluated no...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.nbd.2009.07.010
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- Journal:
- Neurobiology of disease
- Volume:
- 36
- Issue:
- 2
- Pages:
- 242-251
- Publication date:
- 2009-11-05
- DOI:
- EISSN:
-
1095-953X
- ISSN:
-
0969-9961
- URN:
-
uuid:c0b42416-7de4-42d4-8fdd-77f8552ee1c6
- Source identifiers:
-
185112
- Local pid:
- pubs:185112
- Copyright date:
- 2009
Journal article
Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1.
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