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Virus-like particles as carriers for T-cell epitopes: limited inhibition of T-cell priming by carrier-specific antibodies.

Abstract:

Virus-like particles (VLPs) are able to induce cytotoxic T-cell responses in the absence of infection or replication. This makes VLPs promising candidates for the development of recombinant vaccines. However, VLPs are also potent inducers of B-cell responses, and it is generally assumed that such VLP-specific antibodies interfere with the induction of protective immune responses, a phenomenon summarized as carrier suppression. In this study, we investigated the impact of preexisting VLP-speci...

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Authors


Schwarz, K More by this author
Jegerlehner, A More by this author
Manolova, V More by this author
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Journal:
Journal of virology
Volume:
79
Issue:
2
Pages:
717-724
Publication date:
2005-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:c0b0ed65-4ec9-4ff7-9eec-8ef0f1686680
Source identifiers:
469735
Local pid:
pubs:469735

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