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Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits

Abstract:

Family and twin studies have identified endophenotypes that capture familial and genetic risk in attention-deficit/hyperactivity disorder (ADHD), but it remains unclear if they lie on the causal pathway. Here, we illustrate a stepwise approach to identifying intermediate phenotypes. First, we use previous quantitative genetic findings to delineate the expected pattern of genetically correlated phenotypes. Second, we identify overlapping genetic associations with ADHD-related quantitative trai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/ajmg.b.32463

Authors


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ORCID:
0000-0002-1294-4776
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ORCID:
0000-0003-2667-2254
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0002-8432-8622
Cheung, CHM More by this author
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ORCID:
0000-0002-0113-8162
Medical Research Council More from this funder
Publisher:
Wiley Publisher's website
Journal:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Journal website
Volume:
171
Issue:
7
Pages:
982-992
Publication date:
2016-05-27
Acceptance date:
2016-05-12
DOI:
EISSN:
1552-485X
ISSN:
1552-4841
Pubs id:
pubs:625636
URN:
uri:c0ae9db1-130c-4e30-95e6-506c8795f551
UUID:
uuid:c0ae9db1-130c-4e30-95e6-506c8795f551
Local pid:
pubs:625636

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