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An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.

Abstract:

GATA-1 is a tissue-specific transcription factor that is essential for the production of red blood cells. Here we show that overexpression of GATA-1 in erythroid cells inhibits their differentiation, leading to a lethal anaemia. Using chromosome-X-inactivation of a GATA-1 transgene and chimaeric animals, we show that this defect is intrinsic to erythroid cells, but nevertheless cell nonautonomous. Usually, cell nonautonomy is thought to reflect aberrant gene function in cells other than those...

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Publisher copy:
10.1038/35020086

Authors


Lindeboom, F More by this author
Ferreira, R More by this author
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Journal:
Nature
Volume:
406
Issue:
6795
Pages:
519-524
Publication date:
2000-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c0a9e01b-94a8-483f-a4d6-d6d4470dc5a2
Source identifiers:
264233
Local pid:
pubs:264233

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