Journal article

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.

Abstract:: Arylamine N-acetyltransferases (NAT; EC 2.3.1.5) catalyse the transfer of acetyl groups from acetylCoA to xenobiotics, including drugs and carcinogens. The enzyme is found extensively in both eukaryotes and prokaryotes, yet the endogenous roles of NATs are still unclear. In order to study the properties of eukaryotic NATs, high-throughput substrate and inhibitor screens have been developed using pure soluble recombinant Syrian hamster NAT2 (shNAT2) protein. The assay can be used with a wide r...
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Publication status:: Published

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APA Style

Kawamura, A., Graham, J., Mushtaq, A., Tsiftsoglou, S. A., Vath, G., Hanna, P., Wagner, C., & Sim, E. (2005). Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochemical Pharmacology, 69(2), 347–359.

MLA Style

Kawamura, A., et al. “Eukaryotic Arylamine N-Acetyltransferase. Investigation of Substrate Specificity by High-Throughput Screening.” Biochemical Pharmacology, vol. 69, no. 2, 2005, pp. 347–59.

Chicago Style

Kawamura, A, J Graham, A Mushtaq, SA Tsiftsoglou, G Vath, P Hanna, C Wagner, and E Sim. 2005. “Eukaryotic Arylamine N-Acetyltransferase. Investigation of Substrate Specificity by High-Throughput Screening.” Biochemical Pharmacology 69 (2): 347–59.
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Publisher copy:: 10.1016/j.bcp.2004.09.014

Authors

+ Kawamura, A More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Organic Chemistry

Role:

Author

+ Graham, J More by this author

Role:

Author

+ Mushtaq, A More by this author

Role:

Author

+ Tsiftsoglou, SA More by this author

Role:

Author

+ Vath, G More by this author

Role:

Author

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Bibliographic Details

Journal:: Biochemical pharmacology More from this journal
Volume:: 69
Issue:: 2
Pages:: 347-359
Publication date:: 2005-01-01
DOI:: 10.1016/j.bcp.2004.09.014
EISSN:: 1873-2968
ISSN:: 0006-2952

Item Description

Language:: English
Keywords:: Cricetinae

Humans

Chromatography, Gel

Recombinant Proteins

Scattering, Radiation

Rabbits

Substrate Specificity

Animals

Arylamine N-Acetyltransferase

Light

Eukaryotic Cells

Kinetics
Pubs id:: pubs:265600
UUID:: uuid:c09ebf71-a87d-410f-bec4-49e7c1f2c382
Local pid:: pubs:265600
Source identifiers:: 265600
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2005

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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