Journal article
Bench-stable transfer reagent facilitates the generation of trifluoromethyl-sulfonimidamides
- Abstract:
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Sulfonimidamides are an emerging bioisosteric replacement in medicinal chemistry projects, and therefore new chemistries are necessary to access this functionality. The general synthesis of CF3-sulfonimidamides from an activated bench-stable transfer reagent is described. A diverse reaction scope is demonstrated, with a wide range of nucleophilic amines being tolerated in this transformation. The CF3-sulfonimidamides obtained contain an additional diversity point, in the form a protected imin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 521.6KB, Terms of use)
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- Publisher copy:
- 10.1021/acs.joc.8b01244
Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Wright, M
Grant:
EP/L015838/1
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of organic chemistry More from this journal
- Volume:
- 83
- Issue:
- 16
- Pages:
- 9510–9516
- Publication date:
- 2018-06-22
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
- Pmid:
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29932332
Item Description
- Language:
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English
- Pubs id:
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pubs:866270
- UUID:
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uuid:c096c74e-a436-4e9c-833c-ef88627813d0
- Local pid:
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pubs:866270
- Source identifiers:
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866270
- Deposit date:
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2018-11-30
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.joc.8b01244
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