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Journal article

Metabolic profiling predicts response to anti-tumor necrosis factor α therapy in patients with rheumatoid arthritis.

Abstract:

OBJECTIVE: Anti-tumor necrosis factor (anti-TNF) therapies are highly effective in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but a significant number of patients exhibit only a partial or no therapeutic response. Inflammation alters local and systemic metabolism, and TNF plays a role in this. We undertook this study to determine if the patient's metabolic fingerprint prior to therapy could predict responses to anti-TNF agents. METHODS: Urine was collected from 16 RA patients an...

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Publication status:
Published

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Publisher copy:
10.1002/art.37921

Authors


Kapoor, SR More by this author
Fitzpatrick, MA More by this author
Fisher, BA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Arthritis and rheumatism
Volume:
65
Issue:
6
Pages:
1448-1456
Publication date:
2013-06-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:c0956053-2391-4227-88ac-5bdc1deb7c65
Source identifiers:
387851
Local pid:
pubs:387851

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