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Multiscale mechanisms of cell migration during development: Theory and experiment

Abstract:

Long-distance cell migration is an important feature of embryonic development, adult morphogenesis and cancer, yet the mechanisms that drive subpopulations of cells to distinct targets are poorly understood. Here, we use the embryonic neural crest (NC) in tandem with theoretical studies to evaluate model mechanisms of long-distance cell migration. We find that a simple chemotaxis model is insufficient to explain our experimental data. Instead, model simulations predict that NC cell migration ...

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Authors


McLennan, R More by this author
Prather, KW More by this author
Morrison, JA More by this author
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Journal:
Journal of Cell Science
Volume:
125
Issue:
16
Pages:
2935-2944
Publication date:
2012-08-15
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:c08c1769-84f2-4580-899e-1e63120bbeb6
Source identifiers:
366737
Local pid:
pubs:366737

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