Journal article icon

Journal article

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology.

Abstract:

Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP. In the case of PDE2, this regulation primarily involves the allosteric stimulation of cAMP hydrolysis by cGMP. For PDE3, cGMP acts as a competitive inhibitor of cAMP hydrolysis. Several cGMP-mediated responses in cardiac cells, including a potentiatio...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Circulation research
Volume:
100
Issue:
11
Pages:
1569-1578
Publication date:
2007-06-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Source identifiers:
237244
Language:
English
Keywords:
Pubs id:
pubs:237244
UUID:
uuid:c08b48ba-1901-48f7-88eb-617b8d8bb51f
Local pid:
pubs:237244
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP