Journal article
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
- Abstract:
-
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of interleukin-17 (IL-17), in disease pathogenesis. To elucidate its role in MS, brain tissues from patients with MS were compared to controls. We detected expression of IL-17 mRNA (by in situ hybridization) and protein (by immunohistochemistry) in perivascular lymphocytes as well as in astrocytes and oligodendr...
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- Publication status:
- Published
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- Publisher copy:
- 10.2353/ajpath.2008.070690
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Authors
Bibliographic Details
- Journal:
- American journal of pathology
- Volume:
- 172
- Issue:
- 1
- Pages:
- 146-155
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- Source identifiers:
-
241600
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:241600
- UUID:
-
uuid:c086077e-0633-4d5a-a375-79b315ff07d5
- Local pid:
- pubs:241600
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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