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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

Abstract:

Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of interleukin-17 (IL-17), in disease pathogenesis. To elucidate its role in MS, brain tissues from patients with MS were compared to controls. We detected expression of IL-17 mRNA (by in situ hybridization) and protein (by immunohistochemistry) in perivascular lymphocytes as well as in astrocytes and oligodendr...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2008.070690

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
The American journal of pathology
Volume:
172
Issue:
1
Pages:
146-155
Publication date:
2008-01-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:c086077e-0633-4d5a-a375-79b315ff07d5
Source identifiers:
241600
Local pid:
pubs:241600

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