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Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.

Abstract:

Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activit...

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Publication status:
Published

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Publisher copy:
10.1186/bcr313

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Gleadle, J More by this author
Maxwell, PH More by this author
Journal:
Breast cancer research : BCR
Volume:
3
Issue:
5
Pages:
313-317
Publication date:
2001
DOI:
EISSN:
1465-542X
ISSN:
1465-5411
URN:
uuid:c083fe15-3c86-4db6-abb1-f6b793ddc809
Source identifiers:
31962
Local pid:
pubs:31962

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