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Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.

Abstract:

Hepatitis B virus (HBV) infection is thought to be controlled by virus-specific cytotoxic T lymphocytes (CTL). We have recently shown that HBV-specific CTL can abolish HBV replication noncytopathically in the liver of transgenic mice by secreting tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) after antigen recognition. We now demonstrate that hepatocellular HBV replication is also abolished noncytopathically during lymphocytic choriomeningitis virus (LCMV) infection,...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.93.10.4589

Authors


Guidotti, LG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Gresser, I More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
93
Issue:
10
Pages:
4589-4594
Publication date:
1996-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c080d4d0-6990-4124-a445-92d450289096
Source identifiers:
35916
Local pid:
pubs:35916

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