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From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study

Abstract:

Variability refers to differences in physiological function between individuals, which may translate into different disease susceptibility and treatment efficacy. Experiments in human cardiomyocytes face wide variability and restricted tissue access; under these conditions computational models are a useful complementary tool. We conducted a computational and experimental investigation in cardiomyocytes isolated from samples of the right atrial appendage of patients undergoing cardiac surgery ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1152/ajpheart.00477.2017

Authors


Muszkiewicz, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM, RDM Cardiovascular Medicine
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Lawson, BAJ More by this author
Burrage, K More by this author
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Publisher:
American Physiological Society Publisher's website
Journal:
American Journal of Physiology - Heart and Circulatory Physiology Journal website
Volume:
314
Issue:
5
Pages:
H895-H916
Publication date:
2017-12-22
Acceptance date:
2017-12-19
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Pubs id:
pubs:813218
URN:
uri:c07b4fd4-bb7a-42a5-8786-10c315b39de7
UUID:
uuid:c07b4fd4-bb7a-42a5-8786-10c315b39de7
Local pid:
pubs:813218

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