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Journal article

The role of CD4 in HIV binding and entry.

Abstract:

The primary cellular receptor for the human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV is the CD4 antigen (Sattentau et al. 1988; Sattentau and Weiss 1988). HIV infection of CD4+ cells is initiated by binding of the virus to the cell surface, via a high-affinity interaction between the first domain of CD4 and the HIV outer envelope glycoprotein, gp120. The use of a soluble recombinant form of CD4 (sCD4) as a receptor mimic has simplified the analysis of receptor binding and post...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.1993.0136

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, Jenner Institute
Role:
Author
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
342
Issue:
1299
Pages:
59-66
Publication date:
1993-10-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:c0786067-6513-4981-b46e-ba07896c50ed
Source identifiers:
20444
Local pid:
pubs:20444

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