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Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103

Abstract:

Orexins are neuropeptides that regulate the sleep-wake cycle and feeding behaviour. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity, thus playing an important role in energy homeostasis and regulation of appetite. The exact expression and signalling characteristics and physiological actions of QRFP and its receptor GPR103 are poorly understood. Alzheimer's disease (AD) patients experience increased nocturnal activity, excessive daytime sleepiness, and weight l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep12584

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Saunders, N More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
5
Pages:
12584
Publication date:
2015-07-30
Acceptance date:
2015-05-29
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:c06bb4e1-a1d3-4f96-be43-2549df88f3eb
Source identifiers:
535663
Local pid:
pubs:535663
Language:
English
Keywords:

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