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How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Abstract:

The spatiotemporal organisation of membranes is often characterised by the formation of large protein clusters. In Escherichia coli, outer membrane protein (OMP) clustering leads to OMP islands, the formation of which underpins OMP turnover and drives organisation across the cell envelope. Modelling how OMP islands form in order to understand their origin and outer membrane behaviour has been confounded by the inherent difficulties of simulating large numbers of OMPs over meaningful timescale...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-05255-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Funding agency for:
Chavent, M
Grant:
“Mission pour l’interdisciplinarité” PEPS MPI 2017
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Funding agency for:
Beliaev, D
Grant:
Fellowship EP/M002896/1
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Funding agency for:
Kleanthous, C
Grant:
Advanced grant 742555-OMPorg
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Funding agency for:
Kleanthous, C
Grant:
Advanced grant 742555-OMPorg
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
2846
Publication date:
2018-07-20
Acceptance date:
2018-06-15
DOI:
ISSN:
2041-1723
Source identifiers:
857842
Pubs id:
pubs:857842
UUID:
uuid:c060491c-afc7-4f47-9eb6-395a7a5711b0
Local pid:
pubs:857842
Deposit date:
2018-06-17

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