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Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies.

Abstract:

On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind to gliadin and fibronectin fixed to microplates. Furthermore, tTG mediated binding of gliadin to fibronectin coated to microplates. On tissue sections, treatment with sera contain...

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Publication status:
Published

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Publisher copy:
10.3109/08916939808995366

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Viehweg, J More by this author
Journal:
Autoimmunity
Volume:
28
Issue:
4
Pages:
185-195
Publication date:
1998
DOI:
EISSN:
1607-842X
ISSN:
0891-6934
URN:
uuid:c0583577-907c-4a84-82d1-200974c4aa7d
Source identifiers:
95794
Local pid:
pubs:95794

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