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Mepacrine accumulation during treatment of chloroquine-resistant falciparum malaria.

Abstract:

Oral mepacrine dihydrochloride, 200 mg (158 mg of the base) six-hourly for five doses followed by 100 mg (79 mg of the base) eight-hourly for six days (half dosage for those less than or equal to 50 kg) was given to 21 patients with high-grade chloroquine-resistant falciparum malaria in eastern Thailand. Fifteen patients (71%) had a clinical response [fever clearance time of 81 +/- 35 hours (mean +/- S.D.)] and 13 (62%) had complete clearance of parasitaemia (clearance time 92 +/- 42 hours). ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
Annals of tropical medicine and parasitology
Volume:
82
Issue:
2
Pages:
107-112
Publication date:
1988-04-05
EISSN:
1364-8594
ISSN:
0003-4983
URN:
uuid:c0560d7e-cdaf-4c79-8d4d-d9b28a4630ba
Source identifiers:
10338
Local pid:
pubs:10338

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