Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (cartilage oligomeric matrix protein).

Journal article

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint diseases than tendinopathy even though the pathogenesis has many similarities. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patte...

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Authors: Dakin, S; Smith, R; Heinegård, D; Önnerfjord, P; Khabut, A

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 289
• Issue: 8
• Pages: 4919-4927
• Publication date: 2014-02-01
• DOI: 10.1074/jbc.m113.511972
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Amino Acid Sequence; Animals; Horses; Dinoprostone; Chromatography, Liquid; Culture Media; Blotting, Western; Extracellular Matrix; Interleukin-1beta; Tendons; Tissue Survival; Mass Spectrometry; Tendinopathy; Molecular Sequence Data; Cartilage Oligomeric Matrix Protein; Humans; Proteomics