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Journal article

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

Abstract:

Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common to the HLA-DR beta chains of several RA-associated haplotypes. We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients. A highly conserved epitope present on DR beta chains of DR4 and DR1 haplotypes was found in 83% of 149 patients with classical or definite RA but was found in only 46% of 100 co...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.86.24.10049

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
86
Issue:
24
Pages:
10049-10053
Publication date:
1989-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c043585d-0bcb-4759-8249-d30c39e980ac
Source identifiers:
108697
Local pid:
pubs:108697

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