Journal article
Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults
- Abstract:
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Cohorts of healthy younger adults (18-50yrs) and healthy older adults (60-75yrs) were immunized intramuscularly or intranasally with an adenovirus-vectored RSV vaccine (PanAd3-RSV) as a prime dose and boosted with PanAd3-RSV or a poxvirus-vectored vaccine (MVA-RSV) encoding the same insert. Whole blood gene expression was measured at baseline, three- and seven-days post vaccination. Intramuscular prime vaccination with PanAd3-RSV induced differential expression of 643 genes (DEGs, FDR < 0....
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.2MB, Terms of use)
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- Publisher copy:
- 10.1093/cei/uxad003
Authors
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Clinical and Experimental Immunology More from this journal
- Volume:
- 211
- Issue:
- 3
- Pages:
- 269-279
- Publication date:
- 2023-01-09
- Acceptance date:
- 2022-12-08
- DOI:
- EISSN:
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1365-2249
- ISSN:
-
0009-9104
- Pmid:
-
36622786
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1319365
- Local pid:
-
pubs:1319365
- Deposit date:
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2023-01-18
Terms of use
- Copyright holder:
- Green et al.
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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