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The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensible for DNA crosslink repair

Abstract:

FANCM, the most highly conserved component of the Fanconi Anaemia (FA) pathway can resolve recombination intermediates and remodel synthetic replication forks. However, it is not known if these activities are relevant to how this conserved protein activates the FA pathway and promotes DNA crosslink repair. Here we use chicken DT40 cells to systematically dissect the function of the helicase and nuclease domains of FANCM. Our studies reveal that these domains contribute distinct roles in the t...

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Publisher copy:
10.1093/nar/gkp365

Authors


Rosado, IV More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Molecular Medicine
Journal:
Nucleic Acids Research
Volume:
37
Issue:
13
Pages:
4360-4370
Publication date:
2009
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:c03d9cc8-87ff-4f16-acb9-903e25d978df
Source identifiers:
178839
Local pid:
pubs:178839
Language:
English

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