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Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content.

Abstract:

Pancreatic β-cells use Ca(2+)-dependent exocytosis of large dense core vesicles to release insulin. Exocytosis in β-cells has been studied biochemically, biophysically and optically. We have previously developed a biophysical method to monitor release of endogenous intragranular constituents that are co-released with insulin. This technique involves the expression of ionotropic membrane receptors in the β-cell plasma membrane and enables measurements of exocytosis of individual vesicles with ...

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Publication status:
Published

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Publisher copy:
10.1098/rsfs.2010.0006

Authors


Galvanovskis, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Interface focus
Volume:
1
Issue:
1
Pages:
143-152
Publication date:
2011-02-05
DOI:
EISSN:
2042-8901
ISSN:
2042-8898
URN:
uuid:c036934f-7341-4988-bd5e-8ab17820818a
Source identifiers:
221665
Local pid:
pubs:221665

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