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How malaria has affected the human genome and what human genetics can teach us about malaria.

Abstract:

Malaria is a major killer of children worldwide and the strongest known force for evolutionary selection in the recent history of the human genome. The past decade has seen growing evidence of ethnic differences in susceptibility to malaria and of the diverse genetic adaptations to malaria that have arisen in different populations: epidemiological confirmation of the hypotheses that G6PD deficiency, alpha+ thalassemia, and hemoglobin C protect against malaria mortality; the application of nov...

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Publication status:
Published

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Publisher copy:
10.1086/432519

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
American journal of human genetics
Volume:
77
Issue:
2
Pages:
171-192
Publication date:
2005-08-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:c0336624-3316-421a-b7a0-57d7f72388a4
Source identifiers:
33156
Local pid:
pubs:33156

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