- Abstract:
-
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unaccounted for within the genome. Genome-wide complex trait analysis (GCTA) is a statistical method that applies a linear mixed model to estimate phenotypic variance of complex traits explained by genome-wide SNPs, including those not associated with the t...
Expand abstract - Publisher copy:
- 10.1093/hmg/dds335
-
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- Journal:
- Human molecular genetics
- Volume:
- 21
- Issue:
- 22
- Pages:
- 4996-5009
- Publication date:
- 2012-11-05
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- URN:
-
uuid:c02dc967-282f-4ca0-b50b-d641cd8aee7a
- Source identifiers:
-
359679
- Local pid:
- pubs:359679
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
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