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Label-free quantitative proteomics reveals differentially regulated proteins influencing urolithiasis.

Abstract:

Urinary proteins have been implicated as inhibitors of kidney stone formation (urolithiasis). As a proximal fluid, prefiltered by the kidneys, urine is an attractive biofluid for proteomic analysis in urologic conditions. However, it is necessary to correct for variations in urinary concentration. In our study, individual urine samples were normalized for this variation by using a total protein to creatinine ratio. Pooled urine samples were compared in two independent experiments. Differences...

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Publisher copy:
10.1074/mcp.M110.005686

Authors


Wright, CA More by this author
Trudgian, DC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Reynard, JM More by this author
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Journal:
Mol Cell Proteomics
Volume:
10
Issue:
8
Publication date:
2011-08-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:c027c44b-d94a-47da-b34f-31a0c9dbcd62
Source identifiers:
130841
Local pid:
pubs:130841

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